Toxicology & ADME
Hepatotoxicity and renal clearance studies need cell models that preserve organ-specific metabolic and transport function. Cell Biologics supplies primary liver cells — sinusoidal endothelial, epithelial, fibroblast, and Kupffer cell populations — alongside kidney epithelial, glomerular endothelial, and proximal tubular epithelial cells, across mouse and rat.
Pairing the epithelial and non-parenchymal populations from the same organ lets you build co-culture models that better predict in vivo clearance and injury response than a single-cell-type assay.
BUILD A MATCHED PANEL
Build a hepatic co-culture model
Sinusoidal endothelial, fibroblast and epithelial components from matched donors, for hepatotoxicity and clearance co-culture. Kidney populations for renal ADME studies are a species choice away below.
Liver Sinusoidal Endothelial
Hepatic Fibroblasts
Hepatic Epithelial Cells
Toxicology & ADME — frequently asked questions
Do you supply hepatocytes specifically?
Our current liver portfolio covers sinusoidal endothelial, epithelial, fibroblast, and Kupffer cell populations rather than parenchymal hepatocytes. Contact our team — we can advise on the closest validated alternative or source to order.
Which kidney cell type models proximal tubule drug transport?
Proximal Tubular Epithelial Cells are the standard choice for transporter-mediated nephrotoxicity and clearance assays, since the proximal tubule is where most renal drug transporters are expressed.
Not sure which model fits your assay?
Talk to a cell biologist — we help scope isolation, media, and passage strategy at no cost.
